En forgiftning viser sig ofte umiddelbart ved kvalme og opkastninger. En leverskade viser sig derimod først efter nogle dage, med blandt andet påvirkning af hjernen.I slutningen af 1800-tallet fandt en tysk kemiker ud af, at virkningen skyldes stoffet acetylsalicylsyre. Det fik lægemiddelfirmaet Bayer til at udvikle Aspirin og senere Kodimagnyl,

If they wished to produce themselves drunk and out of judgment they chewed a mix of tobacco and coca leaves which make them go since they were out in their wittes.[169][37] In America, copyright is regulated like a Program II drug underneath the Controlled Substances Act, this means that it has a higher possible for abuse but has an approved health